Updates on HIPK2: a resourceful oncosuppressor for clearing cancer
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Updates on HIPK2: a resourceful oncosuppressor for clearing cancer
Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therapies. HIPK2 phosphorylates oncosuppressor p53 for apoptotic activation. In addition, also p53-independent apoptotic pathways are regulated by HIPK2 and can be exploited for anticancer purpo...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2012
ISSN: 1756-9966
DOI: 10.1186/1756-9966-31-63